The veteran writer had been in treatment for a heart condition called cardiac amyloidosis for the past two years before passing outside of his home in Paola, Kansas on May 3.
His wife Mary Stephenson confirmed the sad news to The Hollywood Reporter on Tuesday.
Pepoon also co-created popular Nickelodeon cartoon The Wild Thornberrys which not only had success as a series but also had a 2002 feature film The Wild Thornberrys Movie.
His other credits include ALF, It's Garry Shandling's Show, and Roseanne.
However, his crowning achievement was winning a Primetime Emmy for writing an episode of The Simpsons.
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